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23 Difference Between Batch and Continuous Culture

MN Editors

23 Difference Between Batch and Continuous Culture

Characteristics Batch Culture Continuous Culture
Definition Batch culture refers to a technique used to grow microorganisms in a limited supply of nutrients, which declines when these are used up, or some other factor becomes limiting. Continuous culture refers to a technique used for the production of microbes or microbial products in which nutrients are continuously supplied to the fermenter.
Open/Closed System Batch culture is a closed system Continuous culture is an open system.
Internal Environment The internal environment of batch culture is changed with the progression of the fermentation process. The environment of the continuous culture is not changed during the fermentation process.
Nutrients Nutrients are added at the beginning of the process in batch culture. Nutrients are continuously added to the continuous culture throughout the process.
limiting factor Nutrients become a limiting factor at some point in a batch culture Nutrients are not a limiting factor in a continuous culture
Phases There are three-phase such as Lag, log, and stationary phases. lag and log phases are maintained in a continuous culture.
Continuity The whole process is stopped when the products are formed in a batch culture. The process continues and the products are continuously removed from the fermenter in a continuous culture.
Yield The yield of the batch culture is low. The yield of the continuous culture is significantly high.
Turnover Rate low high
Labor Demand Labor demand is less in a batch culture Labor demand is more in continuous culture.
Chance of Contamination The chance of contamination is less in a batch culture. The chance of contamination is high in batch culture.
Used for Batch culture is suitable for the production of secondary metabolites such as antibiotics. Continuous culture is suitable for the production of primary metabolites such as organic acids and amino acids.
Fermenter Size Large fermenters are used for batch cultures. Small fermenters are used for the continuous cultures.
Control Less control over the growth of the microbes and the production of the desired product. More control on the growth and production.
Nutrient utilization process Nutrient utilization process is slow. Nutrient utilization process is fast.
Washing The fermenter is cleaned and washed before the next step of fermentation. There are no such washing steps are required.
Complexity Batch Culture is Easy to setup Not Easy to setup.
Termination of Process The process of the batch culture is stopped after the product is formed. The process is not stopped though the product is formed. Continuous removal of the product is done without stopping the process in continuous culture.
Environmental Conditions Environmental conditions are not constant. Environmental conditions inside the continuous culture are maintained at constant level.
Controlling Methods Control methods are easy and quick. Control methods are complicated and time-consuming.
Density of bacteria Change with time Remain same



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