Primary databases, in the context of bioinformatics, are comprehensive repositories that store raw experimental data generated from biological studies. These databases serve as central repositories for various types of biological data, including nucleotide sequences, protein sequences, gene expression data, genomic variations, protein structures, and more. Primary databases aim to provide a reliable and accessible source of primary data for researchers and scientists in the field of bioinformatics. They are often managed and maintained by organizations and institutions specializing in biological research, and their data is constantly updated with new findings and discoveries. Researchers can utilize primary databases to access and retrieve specific data sets for further analysis, interpretation, and integration into their research projects.
Primary databases in bioinformatics primarily store:
a) Curated annotations and cross-references
b) Raw experimental data
c) Protein structures
d) Pathway analysis tools
Which of the following is an example of a primary database?
a) GenBank
b) Pfam
c) UniProt
d) KEGG
Primary databases commonly store data such as:
a) Gene ontologies
b) Protein domain annotations
c) Metabolic pathways
d) Raw DNA sequencing reads
The main purpose of primary databases is to:
a) Provide functional annotations
b) Facilitate data integration
c) Store raw experimental data
d) Perform statistical analyses
Which primary database stores DNA and RNA sequences?
a) UniProt
b) PDB (Protein Data Bank)
c) GenBank
d) Reactome
What type of information does the PDB (Protein Data Bank) primarily store?
a) DNA sequences
b) Protein structures
c) Metabolic pathways
d) Gene expression data
How are primary databases different from secondary databases?
a) Primary databases store curated data, while secondary databases store raw data.
b) Primary databases focus on functional annotations, while secondary databases provide pathway information.
c) Primary databases contain raw experimental data, while secondary databases integrate and curate data from primary sources.
d) Primary databases are freely accessible, while secondary databases require a subscription.
Which primary database is commonly used for retrieving protein sequences and related information?
a) GenBank
b) Pfam
c) KEGG
d) Reactome
What is the primary data type stored in GenBank?
a) Protein sequences
b) Gene expression data
c) DNA and RNA sequences
d) Protein structures
Which primary database is focused on cataloging human genetic variation?
a) dbSNP
b) GEO (Gene Expression Omnibus)
c) STRING
d) Ensembl
Which primary database provides information about known protein domains and families?
a) UniProt
b) GenBank
c) PDB (Protein Data Bank)
d) Pfam
How can researchers access primary databases?
a) Through web interfaces or APIs
b) By conducting laboratory experiments
c) By subscribing to scientific journals
d) By attending bioinformatics conferences
The dbSNP database primarily focuses on:
a) Protein-protein interactions
b) DNA sequence variations and single nucleotide polymorphisms (SNPs)
c) Metabolic pathways
d) Gene expression profiles
Which primary database provides information on gene expression profiles and microarray data?
a) GEO (Gene Expression Omnibus)
b) UniProt
c) GenAtlas
d) KEGG
The Ensembl database provides comprehensive information on:
a) Protein structures
b) Metabolic pathways
c) Genome assemblies and annotations
d) Protein domains and motifs
Answers
b) Raw experimental data
a) GenBank
d) Raw DNA sequencing reads
c) Store raw experimental data
c) GenBank
b) Protein structures
c) Primary databases contain raw experimental data, while secondary databases integrate and curate data from primary sources.
a) GenBank
c) DNA and RNA sequences
a) dbSNP
d) Pfam
a) Through web interfaces or APIs
b) DNA sequence variations and single nucleotide polymorphisms (SNPs)
a) GEO (Gene Expression Omnibus)
c) Genome assemblies and annotations
