Protein databases are comprehensive repositories that store and organize information related to proteins. They serve as valuable resources for researchers in the fields of molecular biology, bioinformatics, and structural biology. Protein databases contain a wide range of data, including protein sequences, structures, functions, interactions, and annotations. These databases enable researchers to access and analyze protein-related information, facilitating various studies such as protein structure prediction, protein-protein interactions, protein function annotations, and comparative genomics.
Protein databases often incorporate data from multiple sources, including experimental studies, computational predictions, and literature curation. They provide standardized formats and access methods to ensure the consistency and interoperability of the data. Some commonly used protein databases include UniProt, Protein Data Bank (PDB), Swiss-Prot, RefSeq, and InterPro.
These databases play a crucial role in advancing our understanding of proteins, their roles in biological processes, and their implications in disease mechanisms. They are continuously updated with new data and improvements, making them valuable tools for protein research and facilitating the development of new therapeutics, diagnostics, and biotechnological applications.
Which of the following is a widely used protein database?
a) GenBank
b) PDB
c) UniProt
d) SILVA
Answer: c) UniProt
The Protein Data Bank (PDB) primarily focuses on storing information about:
a) Protein sequences
b) Protein structures
c) Protein interactions
d) Protein functions
Answer: b) Protein structures
Which organization maintains the Protein Data Bank (PDB)?
a) National Center for Biotechnology Information (NCBI)
b) European Molecular Biology Laboratory (EMBL)
c) Protein Data Bank in Europe (PDBe)
d) Worldwide Protein Data Bank (wwPDB)
Answer: d) Worldwide Protein Data Bank (wwPDB)
UniProt is a comprehensive database that provides information on:
a) DNA sequences
b) RNA sequences
c) Protein sequences
d) All of the above
Answer: c) Protein sequences
The UniProt database is a collaborative effort by:
a) European Bioinformatics Institute (EBI) and NCBI
b) European Bioinformatics Institute (EBI) and Protein Data Bank (PDB)
c) National Center for Biotechnology Information (NCBI) and Protein Data Bank (PDB)
d) European Bioinformatics Institute (EBI), Swiss Institute of Bioinformatics (SIB), and Protein Information Resource (PIR)
Answer: a) European Bioinformatics Institute (EBI) and NCBI
Which protein database is known for its comprehensive functional annotations?
a) GenBank
b) PDB
c) UniProt
d) Swiss-Prot
Answer: d) Swiss-Prot
The PDB provides information on protein structures determined by:
a) X-ray crystallography
b) NMR spectroscopy
c) Electron microscopy
d) All of the above
Answer: d) All of the above
Which database focuses on protein families and their evolutionary relationships?
a) PROSITE
b) GenBank
c) Pfam
d) UniProtKB
Answer: c) Pfam
Which database specializes in protein-protein interaction data?
a) STRING
b) GenBank
c) UniProt
d) PDB
Answer: a) STRING
Which protein database provides information on post-translational modifications (PTMs)?
a) PhosphoSitePlus
b) GenBank
c) UniProt
d) PDB
Answer: a) PhosphoSitePlus
The ExPASy Proteomics Server is associated with which protein database?
a) Swiss-Prot
b) GenBank
c) UniProt
d) PDB
Answer: a) Swiss-Prot
Which protein database focuses on protein domain annotations and classifications?
a) InterPro
b) GenBank
c) UniProt
d) PDB
Answer: a) InterPro
The NCBI Protein database is also known as:
a) GenBank
b) Swiss-Prot
c) UniProtKB
d) RefSeq
Answer: d) RefSeq
Which database specializes in the prediction of protein structure and function?
a) Phyre2
b) GenBank
c) UniProt
d) PDB
Answer: a) Phyre2
Which protein database provides information on protein 3D structures in the context of their biological functions?
a) CATH
b) GenBank
c) UniProt
d) PDB
Answer: a) CATH
