AdBlock Detected

It looks like you're using an ad-blocker!

Our team work realy hard to produce quality content on this website and we noticed you have ad-blocking enabled.

X

Chloroquine solution Preparation and Uses

By
MN Editors

Chloroquine solution

  • Molecular Formula of Chloroquine solution: C18H26ClN3 • 2H3PO4
  • Melting point of Chloroquine solution: 193 °C
  • It is a member of the quinoline family with multiple applications. 
  • Solutions can be sterilized by autoclaving or by filtration through a 0.2 µm membrane. Solutions of pH 4-6 are stable when heated, but are sensitive to light.

Chloroquine solution Uses

  • It was originally used as an antimalarial compound. It kills the erythrocytic forms of malaria parasites at all stages of development but does not affect the sporozoites.
  • It is also an antibiotic.4,5 It can be used at 200 mg/ml (PBS, pH 5.0) to dissociate antigenantibody complexes without denaturing red blood cell antigens.
  • A more recent usage is for DNA transfection.7,8 When used at 100 µM, it intercalates into DNA, increasing tranfection efficiency.

Required components for Chloroquine solution

The following components are required to prepare 1L of Chloroquine solution;

Component Amount Concentration
chloroquine diphosphate (mw: 515.86 g/mol) 52 g 0.1008 M
chloroquine diphosphate
chloroquine diphosphate

Chloroquine solution Preparation

  1. Prepare 800 mL of distilled water in a suitable container.
  2. Add 52 g of chloroquine diphosphate to the solution.
  3. Add distilled water until volume is 1 L.
  4. Sterilize the solution by passing it through a 0.22-µm filter; store the filtrate in foil-wrapped tubes at -20°C.

References

We hope you've enjoyed reading our latest blog article! We're thrilled to see the positive response it's been receiving so far. We understand that sometimes, after going through an interesting piece of content, you might have questions or want to delve deeper into the topic.

To facilitate meaningful discussions and encourage knowledge sharing, we've set up a dedicated QNA Forum page related to this specific article. If you have any questions, comments, or thoughts you'd like to share, we invite you to visit the QNA Forum.

QNA Forum Page

Feel free to ask your questions or participate in ongoing discussions. Our team of experts, as well as fellow readers, will be active on the forum to engage with you and provide insightful answers. Remember, sharing your thoughts not only helps you gain a deeper understanding but also contributes to the community's growth and learning. We look forward to hearing from you and fostering an enriching discussion. Thank you for being a part of our journey!

Leave a Comment