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Contribution of Paul Ehrlich and John Snow In Microbiology

MN Editors
Contribution of Paul Ehrlich and John Snow
Contribution of Paul Ehrlich and John Snow

Paul Ehrlich

  • Paul Ehrlich was a Nobel prize-winning German physician and scientist.
  • He mainly worked in the fields of hematology, immunology, and antimicrobial chemotherapy.
  • He was born on 14 March 1854 in Strehlen, Lower Silesia, Prussia.
  • Ehrlich received the Nobel Prize in Physiology or Medicine in 1908, for his contribution to immunology.
  • Paul Ehrlich was the founder of the Paul Ehrlich Institute.
  • He died at the age of 61 on 20 August 1915.

Contributions of Paul Ehrlich

  • Paul Ehrlich discovered the  Mast cell. He visualized it with alkaline dye.
  • He create discovered “neutral” dyes with the combinations of both alkaline and acid dyes. This neutral dyes helps to distinguished lymphocytes among the leucocytes.
  • He discovered the precursors of erythrocytes, by subdividing red blood cells into normoblasts, megaloblasts, microblasts and poikiloblasts. He also demonstrated the existence of nucleated RBCs.
  • He discovered Ehrlich’s reagent, in the earliest time he used it to distinguished different types of typhoid.
  • He reported the acid-fastness of Mycobacterium tuberculosis.
  • He found that the specific effects of immune serum could be demonstrated invivo and invitro.
  • He introduced the method of standardization of toxin and antitoxins.
  • He proposed the “Side-chain theory of antibody production”.
  • He introduced, “Salvaran; an arsenical compound, called the “magical bullet” was capable of destroying the Syphilis.

John Snow

  • John Snow was born on 15 March 1813 in York, United Kingdom.
  • He was an English physician and a leader in the development of anaesthesia and medical hygiene.
  • He is the founder of modern epidemiology.
  • He died at the age of 45 on 16 June 1858.

Contributions of John Snow

  • He study and calculate dosages for the use of ether and chloroform as surgical anaesthetics, allowing patients to undergo surgical and obstetric procedures without the distress and pain they would otherwise experience.
  • He also invented an apparatus to safely administer ether to the patients and designed a mask to administer chloroform.
  • He solved the outbreak of cholera in London in 1854, thus he established that the disease is water-borne. (He showed that cholera is spreading through the [Broad Street] pump)
  • John Snow also called “The Father of Epidemiology”.


Contribution of Paul Ehrlich and John Snow

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