MCQ on DNA Replication


Biology MCQ – MCQ on DNA Replication

1. You isolate a cell strain in which the joining together of Okazaki fragments is impaired and suspect that a mutation has occurred in an enzyme found at the replication fork. The enzyme most likely to be mutated is__________, as this enzyme joins together Okazaki fragments.

2. DNA replicates by which of the following models?

  • conservative
  • semiconservative
  • dispersive
  • none of the above

3. What is the initial mechanism for repairing nucleotide errors in DNA?

  • mismatch repair
  • thymine dimers
  • DNA polymerase proofreading
  • nucleotide excision repair

4. The linear chromosomes in eukaryotes ensure that its ends are replicated completely because telomerase has an inbuilt RNA template that extends the 3′ end, so a primer is synthesized and extended, and the ends are protected.

  • True
  • False

5. Which of the following is the enzyme that replaces the RNA nucleotides in a primer with DNA nucleotides?

  • DNA polymerase III
  • DNA polymerase I
  • primase
  • helicase

6. Which of the following is not involved in the initiation of replication?

  • ligase
  • DNA gyrase
  • single-stranded binding protein
  • primase

7. Which of the following enzymes involved in DNA replication is unique to eukaryotes?

  • helicase
  • DNA polymerase
  • ligase
  • telomerase

8. Which of the following would be synthesized using 5′-CAGTTCGGA-3′ as a template?

  • 3′-AGGCTTGAC-4′
  • 3′-TCCGAACTG-5′
  • 3′-GTCAAGCCT-5′
  • 3′-CAGTTCGGA-5′

9. The enzyme responsible for relaxing supercoiled DNA to allow for the initiation of replication is called __.

10. Unidirectional replication of a circular DNA molecule like a plasmid that involves nicking one DNA strand and displacing it while synthesizing a new strand is called __.


11. More primers are used in lagging strand synthesis than in leading strand synthesis.

  • True
  • False

12. When cell has stalled DNA replication fork, which checkpoint should be predominantly activated?

  • M
  • Both G2/M and M
  • G1/S
  • G2/M

13. Who proposed that dna replication is semiconservative?

  • Meselson and Stahl
  • Watson and Crick

14. particular site at which dna replication starts….

15. how many cycles of dna replication in meiosis?

  • One
  • Two
  • Three
  • No Replication Occurs

16. When DNA replication starts

  • The leading strand produces Okazaki fragments.
  • The hydrogen bonds between the nucleotides of two strands break.
  • The phosphodiester bonds between the adjacent nucleotides break.
  • The bonds between the nitrogen base and deoxyribose sugar break.

17. the stage at which dna/chromosome replication occurs is

  • Prophase
  • Interphase
  • Metaphase
  • Previous telophase.

18. enzyme which do not take part in dna replication is

  • DNA methyltransferase
  • DNA primase
  • DNA topoisomerase
  • DNA ligase

19. which enzyme in dna replication has proofreading ability

  • Ligase
  • Helicase
  • Topoisomerase
  • DNA polymerase
  • Peptidyl transferase.

20. definite region in dna where replication starts is called

  • Promoter region
  • Origin of replication
  • Replication fork
  • Template strand

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