Lysosomes are membranous, spherical sacs that are made up of enzymes. They are acidic hydrolase enzymes that are capable of digesting cellular macromolecules. The membrane of the lysosome helps keep its internal compartments acidic, and also separates the digestion enzymes and the cells’ other components. Lysosome enzymes are created by the proteins of the endoplasmic reticulum , which is then enclosed in vesicles created by the Golgi system. Lysosomes are created by budding out of in the Golgi complex.