Immunological tolerance is a state of specific immunologic nonreactivity to a specific antigen to which an individual has been previously exposed. Immune tolerance stops the immune system from responding to self-antigens.
Natural tolerance is the absence of a response to self-antigens.
It develops throughout embryonic development, and every antigen that contacts the immune system during embryonic development is regarded as self-antigen.
– The development of acquired tolerance occurs when a potential immunogen produces a state of desensitisation to itself.– Antigen must be delivered repeatedly or continuously to maintain acquired tolerance.– This is likely required due to the constant creation of new B and T cells that must be made tolerant.
– The development of acquired tolerance occurs when a potential immunogen produces a state of desensitisation to itself.– Antigen must be delivered repeatedly or continuously to maintain acquired tolerance.– This is likely required due to the constant creation of new B and T cells that must be made tolerant.