MCQ on Nucleotide Databases

Nucleotide databases are repositories that store and provide access to nucleotide sequence data. These databases contain a vast collection of DNA and RNA sequences from various organisms, including viruses, bacteria, plants, animals, and humans. Nucleotide databases play a crucial role in genomics, molecular biology, and bioinformatics research by providing a central location for storing, organizing, and retrieving nucleotide sequence information. They serve as valuable resources for studying genetic variation, gene expression, evolutionary relationships, and functional annotations of nucleotide sequences. These databases often include additional information such as sequence annotations, organism details, experimental methodologies, and associated publications. Some widely used nucleotide databases include GenBank, European Nucleotide Archive (ENA), DNA Data Bank of Japan (DDBJ), and RefSeq. These databases are continuously updated and curated to ensure the accuracy and accessibility of nucleotide sequence information for researchers worldwide.

Which of the following is a commonly used nucleotide database?
a) GenBank
b) PDB
c) UniProt
d) Pfam
Answer: a) GenBank

The GenBank database is maintained by:
a) National Center for Biotechnology Information (NCBI)
b) European Molecular Biology Laboratory (EMBL)
c) Protein Data Bank (PDB)
d) Swiss-Prot
Answer: a) National Center for Biotechnology Information (NCBI)

Which database specifically focuses on sequences from environmental samples?
a) SILVA
b) RefSeq
c) RDP
d) MG-RAST
Answer: d) MG-RAST

Which database provides comprehensive information on rRNA sequences?
a) SILVA
b) GenBank
c) PDB
d) UniProt
Answer: a) SILVA

The RefSeq database includes curated and non-redundant sequences for:
a) Proteins
b) Nucleotides
c) Both proteins and nucleotides
d) Metagenomic data
Answer: c) Both proteins and nucleotides

Which database focuses on small RNA sequences, including microRNAs?
a) miRBase
b) GenBank
c) RefSeq
d) PDB
Answer: a) miRBase

The ENA (European Nucleotide Archive) is a collaborative database maintained by:
a) EMBL-EBI, DDBJ, and NCBI
b) NCBI and EMBL-EBI
c) NCBI and DDBJ
d) DDBJ and EMBL-EBI
Answer: a) EMBL-EBI, DDBJ, and NCBI

Which database provides comprehensive information on non-coding RNA sequences?
a) NONCODE
b) GenBank
c) RefSeq
d) PDB
Answer: a) NONCODE

Which database focuses on plant-specific nucleotide sequences?
a) PlantGDB
b) GenBank
c) RefSeq
d) PDB
Answer: a) PlantGDB

Which database specializes in viral nucleotide sequences?
a) ViralZone
b) GenBank
c) RefSeq
d) PDB
Answer: a) ViralZone

Which database is widely used for identifying and analyzing promoter sequences?
a) EPD (Eukaryotic Promoter Database)
b) GenBank
c) RefSeq
d) PDB
Answer: a) EPD (Eukaryotic Promoter Database)

Which database provides comprehensive information on non-coding RNA genes and their promoters?
a) RFAM
b) GenBank
c) RefSeq
d) PDB
Answer: a) RFAM

Which database focuses on mitochondrial genome sequences?
a) MitoCarta
b) GenBank
c) RefSeq
d) PDB
Answer: a) MitoCarta

Which database provides information on nucleotide variations and their association with diseases?
a) dbSNP
b) GenBank
c) RefSeq
d) PDB
Answer: a) dbSNP

Which database specializes in ribosomal RNA sequences?
a) RDP (Ribosomal Database Project)
b) GenBank
c) RefSeq
d) PDB
Answer: a) RDP (Ribosomal Database Project)

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